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Dosage of MISOPROSTOL
These problems were: (1) rapid metabolism resulting in a lack of oral activity and a short duration of action when given parenterally, (2) numerous side effects, and misoprostol (3) chemical instability leading to a short shelf life .
Misoprostol differs structurally from prostaglandin E by the presence of a methyl ester at C-1, a methyl group at misoprostol C-16 and a hydroxyl group at C-16 rather than at C-15 .
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