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[6] Hepatic Impairment, mild impairment tapentadol (Child-Pugh class A): no dosage adjustment necessary .
Moderate impairment (Child-Pugh class B): extended tapentadol release: initial: 50 mg every 24 hours or longer; maximum: 100 mg once daily .
Severe tapentadol combination nucynta wiki tapentadol nzt tapentadol fda approval nucynta label tapentadol impairment (Child-Pugh class C): not recommended there is no study in this patient population .
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