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Concomitant administration with carbamazepine, an tramadol inducer of hepatic enzymes, reduced the t1⁄2β of tramadol by ≈50% .
Clinical Efficacy The analgesic efficacy of intravenous, intramuscular and oral tramadol has been established in several randomised, double-blind, parallel-group, comparative studies in tramadol adult patients with moderate to severe acute postoperative pain, and in a limited number of studies in paediatric patients .