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Compared with oxycodone IR, the adverse event profile of tapentadol IR suggested a similar central nervous system tolerability and tapentadol a better gastrointestinal tolerability (Hale et al .
Safety in Phase II and Phase III trials of tapentadol PR The most common adverse drug tapentadol reactions (≥10% subjects) observed with tapentadol PR treatment in the dose range of 50 mg to 250 mg twice daily were nausea, dizziness, somnolence, headache, and constipation .

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