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The mucosa lining the oral cavity is affected by many inflammatory, atrophic and ulcerative conditions for which topical steroids are an appropriate treatment. The physical environment of the mouth creates unique problems in drug delivery, and many strategies have been proposed in an attempt to overcome the difficulties. Triamcinolone is commonly used in various conditions and is available in oral, nasal, injectable, topical, ophthalmic injection, and spray preparations. Triamcinolone was first approved by the fda in 1957. Like other corticosteroids, triamcinolone has anti-inflammatory and antipruritic (anti- itch) properties. Other risk factors include antibiotic therapy, xerostomia, uncontrolled diabetes mellitus, immunosuppression, corticosteroids (both systemic and inhaled), and poor oral hygiene (peterson, 1992). Soft-white elevated plaques present on mucosal membranes. Oral candidiasis, also known as oral thrush among other names, is candidiasis that occurs in the mouth. That is, oral candidiasis is a mycosis (yeast/fungal infection) of candida species on the mucous membranes of the mouth. Candida albicans is the most commonly implicated organism in this condition. The oral cavity is the point of entry for oral drug formulations but usually their contact with the oral mucosa is brief. In order to take advantage of some of the properties of the oral mucosa or to locally treat the mucosa, delivery systems have been designed to prolong residence in this area. Also gentle pressure of the normal mucosa induced a positive nikolsky’s sign. An incisional biopsy was performed on this area and submitted for histopathological examination. Biopsy specimens from the oral mucosa revealed partial junctional separation at the level of the basement membrane, suggestive of mmp (figure 4). About 50% of patients who have oral lesions also present with skin lesions. 13 the tongue and buccal mucosa are the most frequent sites. Among the different forms of lichen planus, the reticular form is the most common and appears as slightly elevated, fine, white lines called wickham's striae , which have a lace-like pattern. Prednisone is the oral tablet form of steroid most often used. 5 mg per day is generally considered a low dose; up to 40 mg daily is a moderate dose; and more than 40-mg daily is a high dose. Conclusions: the results of this meta-analysis from current evidence showed that compared with conventional treatment, s miltiorrhiza injection combined with steroid could significantly improve the maximal mouth opening and the subjective symptom burning sensation as well as decrease the oral mucosal lesion area without increasing adverse effects. For symptomatic olp, topical steroids, such as triamcinolone mouthwash or mixed with orabase, clobetasol or fluocinonide are used first in treatment. If the olp is severe or affects large areas of the oral mucosa, systemic corticosteroids should be prescribed. For 10-14 days with oral steroids given in high doses [3, 10]. It should be noted that abnormal resting lung function in itself, that does not return to normal after a course of oral steroids, does not indicate sra. There are many patients with severe, long-standing disease, whose expira­. Corticosteroid drugs are widely used in oral medicine such as in vesiculobullous diseases, orofacial granulomatosis, temporal arteritis and other oral mucosal disorders. Topical corticosteroids should be considered the treatment of choice unless the disease is very extensive. Systemic therapy is reserved for those with severe, refractory disease

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